VACHAL, Petr,RAHEEM, Izzat T.,GUO, Zhiqiang,HARTINGH, Timothy John
申请号：
PE2018000216
公开号：
PE20181016A1
申请日:
2016.08.08
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The invention refers to a formula compound I, wherein R1 and R2 are selected from h-c1-c4 tar, ch2-phenyl and other substances respectively； R3 is an unreplaced C1-C10 tar, ch2-phenyl, unreplaced arilo and other substances； RA is an unreplaced l-carbamate I, Among other things, there is another alcohol of D-amino acid； R4 is - C1-C4, ch2-phenol, arilo； R9 is - C1-C10, ch2-phenyl, and arilo is not replaced. The most popular compounds are n - [(s) - [(1R) - 2 - (6-amino-9h-purin-9-il) - 1-methyletoxi] methyl} [(2S) - 2-methyl-3 - (1-methyletoxi) - 3-oxopropil] amine} phosphorus] - l-alanino 1-methylethyl；N - [(R) - [(1R) - 2 - (6-amino-9h-purin-9-il) - 1-methyletoxi] methyl} [(2S) - 2-methyl-3 - (1-methyletoxi) - 3-oxopropil] amine} phospholipid] - l-alanito 1-metallic, et al The present invention also refers to a pharmacological composition that includes an effective amount of one or more HIV antiviral agents, such as abacavir, efavirenz and others, as well as a pharmaceutically acceptable vehicle. It helps to suppress reverse transcription of HIV, which is not only helpful for prevention, treatment and prevention, but also helps to delay the emergence or development of AIDS and / or AIDS.La presente invencion refiere un compuesto de formula I, en la que R1 y R2 se seleccionan cada uno independientemente entre H, -alquilo C1-C4, -CH2-fenilo, entre otros； R3 es -alquilo C1-C10 no sustituido, -CH2-fenilo no sustituido, arilo no sustituido, entre otros； RA es un resto de ester de L-aminoacido de formula i, un resto de ester de D-aminoacido de formula ii, entre otros； R4 es -alquilo C1-C4, -CH2-fenol, arilo； R9 es -alquilo C1-C10, -CH2-fenilo, arilo no sustituido, entre otros. Son compuestos favoritos: N-[(S)-{[(1R)-2-(6-amino-9H-purin-9-il)-1-metiletoxi]metil}{[(2S)-2-metil-3-(1-metiletoxi)-3-oxopropil]amino}fosforil]-L-alaninato 1-metiletilico； N-[(R)-{[(1R)-2-(6-amino-9H-purin-9-il)-1-metiletoxi]metil}{[(2S)-2-metil-3-(1-metiletoxi)-3-oxopropil]amino}fosforil]-L-alani
