GlaxoSmithKline Intellectual Property Development Limited
发明人:
申请号：
EP18161946.1
公开号：
EP3366691A1
申请日:
2016.12.01
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
A compound of Formula (VI) wherein R58 and R59 are independently selected from: H, CH2OC(O)R57, CH2OCO2R57, CH2CH2SC(O)R57, and CH2CH2SSCH2R57； provided that at least one of R58 and R59 is not H； R56 is F； X51O； X52is O.Pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
