A compound of Formula (I) wherein Y 1 Y2 X 1 X 2 R 1 R 2 R3 R4 R5 R6 R8 and R9 are as defined herein； and pharmaceutically acceptable salts and tautomers thereof compositions combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds combinations compositions and medicaments in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial for example inflammation allergic and autoimmune diseases infectious diseases cancer pre cancerous syndromes and as vaccine adjuvants.
