The present invention relates to vesicles derived from a bacterium of the genus Cupriavidus and uses thereof. The present inventors compared with normal people, gastric cancer, colon cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, prostate cancer, head and neck cancer, malignant diseases such as lymphoma, cardiomyopathy, atrial fibrillation, Heart vesicles such as variant angina, chronic obstructive pulmonary disease, stroke, diabetes, renal failure, dementia, Parkinson's disease and depression, the vesicles are significantly reduced, and the vesicles are pathogenic. It significantly suppressed the secretion of inflammatory mediators by sex vesicles and at the same time suppressed the development of cancer. Vesicles derived from cupriawidus bacterium according to the present invention, gastric cancer, colon cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, prostate cancer, head and neck cancer, lymphoma and other malignant diseases, cardiomyopathy, Atrial fibrillation, heart disease such as variant angina, chronic obstructive pulmonary disease, stroke, diabetes, renal failure, dementia, Parkinson's disease or depression, and a method for preventing or treating the disease are developed. Useful for the purpose. [Selection diagram] None本発明は、クプリアウィドゥス属細菌由来の小胞及びその使用に関する。本発明者らは、正常人に比べて胃癌、大腸癌、膵臓癌、胆管癌、乳癌、卵巣癌、膀胱癌、前立腺癌、頭頸部癌、リンパ腫などの悪性疾患、心筋病症、心房細動、異形狭心症などの心臓疾患、慢性閉塞性肺疾患、脳卒中、糖尿病、腎不全、認知症、パーキンソン病及び鬱病などの患者のサンプルで前記小胞が有意に減少され、前記小胞は、病原性小胞による炎症媒介体の分泌を有意に抑制すると同時に癌発生を抑制した。本発明によるクプリアウィドゥス属細菌由来の小胞は、胃癌、大腸癌、膵臓癌、胆管癌、乳癌、卵巣癌、膀胱癌、前立腺癌、頭頸部癌、リンパ腫などの悪性疾患、心筋病症、心房細動、異形狭心症などの心臓疾患、慢性閉塞性肺疾患、脳卒中、糖尿病、腎不全、認知症、パーキンソン病又は鬱病の診断方法、及び前記疾患の予防又は治療用組成物を開発するための目的で有用である。【選択図】なし
