Armin Giese;Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.;Felix Schmidt
发明人:
Ryazanov, Sergey,Giese, Armin,Schmidt, Felix,Griesinger, Christian,Leonov, Andrei
申请号：
AU2016372408
公开号：
AU2016372408A1
申请日:
2016.12.14
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention is concerned with derivatives of 3,5-diphenyl-diazole derivatives, which are effective therapeutic agents for use in treating diseases linked to protein aggregation and/or neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD). and Transmissible spongi form encephalopathies (TSEs) such as Creutzfeldt- Jakob disease CJD). Formula :(I) The therapeutic effect is caused by the inhibition of the protein aggregation in the affected tissue, such as the brain, 3,5-Diphenyl-diazole derivatives have been shown to be effective in inhibiting aggregation of proteins but arc also characterized by their poor solubility in aqueous solutions. The prodrugs of the invention are modified 3,5-diphenyl-diazole derivatives, which are characterized by their improved solubility in aqueous solutions, and by their increased bioavailability.
