PROBLEM TO BE SOLVED: To provide an image reconstruction device or method for imaging magnetic nanoparticles distributed in space, wherein the resolution power of reconstructed images is improved and the influences of false images is reduced and removed.SOLUTION: The image reconstruction device 10 has an image reconstruction means 4 to reconstruct magnetic response signals as an image information. The image reconstruction means 4 obtains an ideal waveform to be compared with the magnetic response waveform detected in an unsaturated region by a detection means. The image reconstruction means calculates difference information between the ideal waveform and the magnetic response waveform as the factor for correction, and uses the correction factor for weighting the signal strength of the magnetic response waveform. Prior to weighting the signal strength, the image reconstruction means 4 may normalize the magnetic response waveform by its maximum oscillation value, after subtracting the offset component wmean of the magnetic response signal waveform from the magnetic response signal waveform. The ideal waveform may be a magnetic response signal waveform that can be detected in the case where the magnetic nanoparticles are arranged in the same space as an unsaturated region.COPYRIGHT: (C)2010,JPO&INPIT【課題】磁性ナノ粒子の空間的分布を画像化する画像再構成装置又は画像再構成方法において再構成画像の分解能を改善し、偽像の影響を軽減・排除する。【解決手段】画像再構成装置10は、磁化応答信号を画像情報として再構成する再構成手段4を備える。再構成手段4は検出手段によって非飽和領域において検出された磁化応答波形と比較すべき理想波形を取得する。再構成手段は、理想波形と磁化応答波形との差分情報を補正係数として算出して該補正係数により前記磁化応答波形の信号強度に重み付けを行うことを特徴とする。再構成手段4は、重み付けを行う前に磁化応答信号波形から磁化応答波形のオフセット成分wmeanを減じた後に磁化応答波形の振幅最大値で正規化してもよい。理想波形は、非飽和領域と同一の空間位置に磁性ナノ粒子が配置された場合に検出される磁化応答信号波形であってもよい。【選択図】図6
