PROBLEM TO BE SOLVED: To provide compositions for imaging amyloid deposits and neurofibrillary tangles (NFTs, also known as paired helical filaments, PHFs).SOLUTION: A pharmaceutical composition comprises: functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to β-amyloid deposits and/or neurofibrillary tangles and a pharmaceutically acceptable carrier. Preferably, the functional group is 2-(1-{6-[(2-hydroxyethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (HODDNP), or a derivative or analog thereof.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】アミロイド沈着物および神経原繊維濃縮体(NFT;対合らせん状フィラメントPHFとしても既知)を画像処理するための組成物の提供。【解決手段】β-アミロイド沈着物および/または神経原繊維濃縮体と結合する官能基を含む機能性磁性ナノ粒子(MNP)と製薬上許容可能な担体を含む薬学的組成物。好ましくは、前記官能基が、2-(1-{6-[(2-ヒドロキシエチル)(メチル)アミノ]-2-ナフチル}エチリデン)マロノニトリル(HODDNP)またはその誘導体もしくは類似体である薬学的組成物。【選択図】なし
