PREPARATION OF CONTROLLED RELEASE SKELETAL MUSCLE RELAXANT DOSAGE FORMS COMPRISING CYCLOBENZAPRINE

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专利权人:

INC.;APTALIS PHARMATECH

发明人:

VENKATESH, GOPI,CLEVENGER, JAMES, M,GRINSTEAD, TIMOTHY

申请号：

NZ58985609

公开号：

NZ589856A

申请日:

2009.06.18

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a method of preparing a pharmaceutical composition comprising: a) coating inert particles with a drug layering composition comprising cyclobenzaprine or a pharmaceutically acceptable salt, solvate, and/or ester thereof, and a pharmaceutically acceptable solvent, thereby forming immediate release (IR) beads； and b) coating the IR beads with an extended release (ER) coating composition comprising a pharmaceutically acceptable water-insoluble polymer, under an atmosphere having a dew point ranging from about 5-20 degrees C, thereby forming ER beads.

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