The present invention provides a fusion protein comprising an immunostimulatorypolypeptide and a mutant E7 protein of a human papilloma virus. The present inventionalso provides a gene encoding the fusion protein, expression vectors containingthe gene, a pharmaceutical composition comprising the fusion protein, a methodfor treating or preventing a human papilloma virus related disease by using thefusion protein and uses of the fusion protein in the preparation of a medicamentfor the treatment or prevention of the human papilloma virus related disease.