THE REGENTS OF THE UNIVERSITY OF COLORADO; A BODY CORPORATE
发明人:
ROBERT L. GARCEA,DENNIS G. MACEJAK
申请号：
US16530786
公开号：
US20200121779A1
申请日:
2019.08.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Embodiments of the present invention provide compositions and methods for recombinantly generating tagless constructs of proteins or peptides. In certain embodiments, recombinant proteins or peptides disclosed herein concern human papilloma virus (HPV). Other embodiments concern using these constructs in compositions to elicit immune responses in a subject to one or more HPV types. Therapeutic and prophylactic vaccines for the prevention and treatment of viral infections are also disclosed. Nucleic acids and expression vectors coding for constructs contemplated herein are provided. In certain embodiments, an HPV capsid protein generated is devoid of any fusion tags. In addition, truncated forms of HPV L1 are contemplated.
