LE DOUSSAL JEAN MARC,TERME MICKAËL,DORVILLIUS MYLENE
申请号：
IN201637016620
公开号：
IN201637016620A
申请日:
2016.05.12
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention concerns an antibody, or functional fragment thereof, which binds specifically to the O-acetylated-GD2 ganglioside, said antibody comprising a) a light chain comprising three light chain complementary regions (CDRs) having the following amino acid sequences: the light chain CDR1 : QSLLKNNGNTFL (SEQ id n�l), the light chain CDR2: KVS, the light chain CDR3: SQSTHIPYT (SEQ id n�2) and a light chain framework sequence from an immunoglobulin light chain, wherein said framework sequence comprises the human kappa (K)CL domain and b) a heavy chain comprising three heavy chain complementary regions (CDRs) having the following amino acid sequences: the heavy chain CDR1 : EFTFTDYY (SEQ id n�3), the heavy chain CDR2: IRNRANGYTT (SEQ id n�4), the heavy chain CDR3: ARVSNWAFDY (SEQ id n�5), and a heavy chain framework sequence from an immunoglobulin heavy chain, wherein said framework sequence comprises the CH2 and CH3 domains from a human IgGl, and a CHI domain from a human IgG1 which is mutated so as to restore the pairing between CH1 and light chain that is typical of other human IgG subclasses or substituted by a CH1 domain from such non-IgG1 subclasses as human IgG2, IgG3 or IgG4 and its use in therapy.
