James P. Collman,Paul Clifford Herrmann,David Alvin Tyvoll,Richard Decreau,Brian Stanley Bull,Christopher Jeffrey Barile
申请号：
US13093825
公开号：
US09918964B2
申请日:
2011.04.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more platelet functions including clumping, sticking or platelet-stimulated clotting. Thus diseases or disorders mediated by inappropriately high levels of platelet activation or platelet aggregation can be treated by administering a therapeutically effective amount of a heterocyclic compound or nonheterocyclic mitochondrial inhibitor that significantly reduces one or more platelet functions including clumping, sticking or platelet-stimulated clotting, preferably in a reversible manner.
