Process for producing crystals of polymorphic 2-(3-cyano-4-isobutyloxyphenyl) -4-methyl-5-thiazolecaboxylic acid by poor-solvent addition method

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专利权人:

Teijin Pharma Limited

发明人:

Uemura, Akihito,Nogata, Tomoaki,Takeyasu, Takumi

申请号：

AU2010271717

公开号：

AU2010271717A8

申请日:

2010.07.14

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole­carboxylic acid, the process comprising the step of heating and dissolving 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl­5-thiazole-carboxylic acid in one or more solvents, as good solvents, selected from a group consisting of 1-propanol, 2-propanol, ethanol, and acetone, the step of cooling the solution, and the step of adding a hydrocarbon solvent as a poor solvent to the cooled solution.

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