A transducer supported by a positioning arrangement is placed within a renal artery at a desired location that is a predetermined distance from a reflector equal to an odd number of quarter wavelengths of acoustic energy emitted by the transducer. The positioning arrangement is actuated to transition from a low-profile introduction configuration to a deployed configuration within the renal artery thereby stabilizing the transducer at a desired location. Acoustic energy is emitted by the transducer so that it propagates axially along an outer surface of the target vessel to impinge the reflector, which can be biological or artificial. The emitted energy builds up to resonance at a point of reflection defined by a location of the reflector, and the amount of energy build up is sufficient to ablate perivascular renal nerves in the vicinity of the reflector.
