Process for the preparation of darunavir

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专利权人:

Siva Rama Prasad Vellanki

发明人:

Siva Rama Prasad Vellanki,Arabinda Sahu,Aravind Kumar Katukuri,Vikram Vanama,Satishbabu Kothari,Venkata Suryanarayana Ponnekanti,Debashish Datta

申请号：

US13496642

公开号：

US08703980B2

申请日:

2010.09.16

申请国别(地区):

US

年份:

2014

代理人:

摘要：

A process for the preparation of Darunavir comprises the reacting of 4-amino-N-(2R, 3S) (3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-benzenesulfonamide with (3R, 3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivative in N-methyl-2-pyrrolidinone and isolating the resulting Darunavir. The process yields Darunavir with a very low level of the difuranyl impurity.

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