Disclosed is a compound represented by the following general formula: (wherein R<；SUP>；1<；/SUP>； represents a hydrogen atom or the like； R<；SUP>；2<；/SUP>； represents an optionally substituted alkyl or aryl group or the like； R<；SUP>；3<；/SUP>； and R<；SUP>；4<；/SUP>； may be the same or different and each represents an aryl group or the like； R<；SUP>；5<；/SUP>； represents a hydrogen atom or the like； X<；SUP>；1<；/SUP>； represents an alkylene group, a bonding hand or the like； X<；SUP>；2<；/SUP>； represents a bonding hand or the like； Y<；SUP>；1<；/SUP>； represents a bonding hand or the like； and Z<；SUP>；1<；/SUP>； and Z<；SUP>；2<；/SUP>； each represents CH or the like) or a salt thereof. Since the compound or a salt thereof has a strong PGE<；SUB>；2<；/SUB>； production inhibitory activity, it is useful for treatment or prevention of diseases and conditions associated with PGE<；SUB>；2<；/SUB>；.
