The invention provides a signal oral dose pharmaceutical composition comprising, triple combination of entacepone, levodapa and carbidopa, or salts thereof along with one or more sugar alcohols wherein entacapone is co-micronized with sugar alcohol, characterized in that one or both of the rate and the absorption of composition comprising triple combination of entacepone, levodapa and carbidopa, or salts thereof is equal to or greater than that obtained by a triple combination of entacepone, levodapa and carbidopa formulation markted under the trade name Stalevo200(R).