Judi Charlotte Neuss;Daniel Christopher Brookings;James Andrew Johnson;Joanna Rachel Thorne;Barry John Langham
发明人:
James Andrew Johnson,Daniel Christopher Brookings,Barry John Langham,Judi Charlotte Neuss,Joanna Rachel Thorne
申请号：
US12971590
公开号：
US08637491B2
申请日:
2010.12.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A series of thieno[2,3-b]pyridine derivatives, attached at the 2-position to a substituted anilino moiety, which are substituted in the 3-position by a carbonyl group linked to a pyrrolidin-1-yl ring which in turn forms part of a heteroatom-containing fused bicyclic ring system, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.
