Compounds derived from N - [1-cyano-2 - (phenyl) ethyl] - 2-azabicyclo [2.2.1] - 3 - heptan carboxamidas replaced, inhibitors of cathepsin C； Pharmaceutical composition； method of treatment； and use for the treatment of diseases such as Asthma, Allergic diseases, rheumatoid arthritis, and Atherosclerosis, among others.
RIETHER, DORIS,OOST THORSTEN,GRUNDL, MARC,PAUTSCH, ALEXANDER,PETERS, STEFAN,WIENEN, WOLFGANG
申请号：
CL2014000299
公开号：
CL2014000299A1
申请日:
2014.02.06
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention is directed to compounds of Formula I: wherein R1, R2 and n are described herein. These compounds and their pharmaceutically acceptable salts thereof are inhibitors of Cathepsin C.COMPUESTOS DERIVADOS DE N-[1-CIANO-2-(FENIL)ETIL]-2-AZABICICLO[2.2.1]HEPTAN-3-CARBOXAMIDA Y SUS SALES, INHIBIDORES DE DPPI； COMPOSICIONES FARMACEUTICAS； COMBINACIONES FARMACEUTICAS； USO PARA EL TRATAMIENTO DE ASMA, ENFERMEDADES ALERGICAS, INFLAMATORIAS GASTROINTESTINALES, EOSINOFILICAS, PULMONAR OBSTRUCTIVA CRONICA, INFECCIONES POR MICROBIOS PATOGENOS, ENTRE OTRAS.
