Triazolone derivatives compounds as inhibitors of mpges-1； Process of preparing such Compounds, Pharmaceutical composition that comprises, useful for the treatment of inflammation, Asthma, COPD, arthritis, Parkinson's disease and autoimmune diseases, among other diseases.
The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.<；p>；La presente invenció；n se refiere a compuestos de fó；rmula (I), y sales de los mismos farmacé；uticamente aceptables, como inhibidores de mPGES-1. Estos compuestos son inhibidores de la enzima sintasa-1 de Prostaglandina microsomal (mPGES-1) y son por lo tanto ú；tiles en el tratamiento de dolor y/o inflamació；n a partir de una variedad de enfermedades o condiciones, tales como asma, osteoartritis, artritis reumatoide, dolor agudo o cró；nico y enfermedades neurodegenerativas. Tambié；n la presente invenció；n presenta Ia composició；n farmacé；utica y el procedimiento de preparació；n.<；/p>；
