MCCARRON, ASHLEY, SUE,SELLS, TODD, B.,STIRLING, MATTHEW,STROUD, STEPHEN, G.
申请号：
SG11201400102W
公开号：
SG11201400102WA
申请日:
2012.08.23
申请国别(地区):
SG
年份:
2014
代理人:
摘要：
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1 S ,2 S ,4 R )-4-[(6-{[(1 R ,2 S )-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof； solid state forms thereof； and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
