The objective of the invention is to obtain a kind of integrin α8β1 binding antibodies which can bind with integrin α8β1 originated from many different types of mammals. In addition, the invention relates to get a kind of integrin α8β1 binding antibodies which contains the effect of inhibiting the combination of integrinα8β1 and ligands. The current invention provides the integrin α8β1 binding antibodies which can bind with integrin α8β1 originated from many different types of mammals. And the invention acquires an inhibitor comprising the integrin α8β1 binding antibodies, which can inhibit the combination of integrinα8β1 and ligands.本發明所要解決的課題是為了獲取能夠與多個不同種類哺乳動物來源的嵌合素α8β1結合的嵌合素α8β1結合性抗體。以及具有抑制嵌合素α8β1與配位體相結合效果的嵌合素α8β1結合性抗體。藉由本發明，最終獲得了能夠與多個不同種類哺乳動物來源的嵌合素α8β1結合的嵌合素α8β1結合性抗體。還獲得了可抑制嵌合素α8β1與配位體相結合的包含嵌合素α8β1結合性抗體的抑制劑。
