The present invention relates to a process for the selection of anti c-Met antibodies capable to inhibit both ligand-dependent and ligand-independent activation of c-Met. More particularly, said process is based on the inhibition of the c-Met dimerization.In another aspect, the present invention concerns such antibodies and compositions comprising such antibodies for the preparation of a medicament to treat cancer. Diagnosis process and kits are also part of the invention.本發明係相關於一種篩選c-Met抗體，其可抑制配位體依賴型與非配位體依賴型之c-Met活化，之方法。更特別的是，該方法係以抑制c-Met二聚化為基礎。另一方面，本發明係相關於使用此抗體，與包含此抗體之組成物，製備治療癌症之藥物。診斷方法與套組亦為本發明之一部份。
