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COMPOSITION PHARMACEUTIQUE A TENEUR EN DERIVE DE POLYMERE DE CAMPTOTHECINE
专利权人:
NIPPON KAYAKU KABUSHIKI KAISHA
发明人:
AOKI, SHIN,FUJITA, SHINYA
申请号:
CA2995053
公开号:
CA2995053A1
申请日:
2016.08.25
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
[Problem] The problem is to provide a pharmaceutical formulation containing a polymerized camptothecin derivative obtained by bonding a camptothecin derivative having the ability to form nanoparticles by association in aqueous solution to a polymer carrier, wherein the pharmaceutical formulation composition has improved formulation stability. In particular, the problem is to provide a pharmaceutical formulation having excellent storage stability that maintains the ability to form nanoparticles and the camptothecin derivative bonding stability, which are important factors. [Solution] A pharmaceutical formulation containing a block copolymer linking a polyethylene glycol segment and a polyglutamic acid segment including a camptothecin derivative bonded to a glutamic acid unit, and a saccharide, wherein the pharmaceutical formulation forms aggregates in aqueous solution, and the change in the scattered light intensity of the aggregates in the pharmaceutical formulation is 20% or less after the pharmaceutical formulation has been stored for four weeks at 40°C shielded from light.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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