Drug compositions for treatment of one or more inflammatory conditions can includes at least one of a theta defensin analog or derivative thereof. Inventive methods include researching theta defensins analogs or derivatives thereof for their efficacy with respect to anti inflammatory effects and providing such compositions to the market place for the purpose of treating inflammatory conditions. Of particular interest are drug compositions effective to produce clinically relevant inhibition of tumor necrosis factor alpha (TNF alpha) converting enzyme (TACE) or other proinflammatory proteases and/or sheddases such as RTD 1 27 RTD 1 28 or RTD 1 29. It is contemplated that preferred compositions can be used to treat rheumatoid arthritis inflammatory bowel disease and other chronic inflammatory diseases autoimmune diseases cancer and Alzheimer s osteoarthritis inflammation related neurodegenerative and other inflammation related diseases.
