Biphenylcarboxamide derivatives as hedgehog pathway modulators

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专利权人:

IRM LLC

发明人:

Dierks, Christine,Warmuth, Markus,Wu, Xu

申请号：

AU2012202646

公开号：

AU2012202646A1

申请日:

2012.05.04

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2012202646A120120524.pdf#####C:\NRPonbUlCC\KXG\J3"2679_1 DOC.IM5/201 2 ABSTRACT The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula 1. R1 R5 R2 Ra R3 RG R7 H N Re 0 Y2 R9

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