121 122 122 123 834524 24Provided are compounds having excellent Syk inhibitory activity and pharmaceutical compositions. Specifically provided are: nicotinamide derivatives represented by general formula (I) or salts thereof and pharmaceutical compositions for the treatment of Syk related diseases which contain the nicotinamide derivatives or the salts thereof. In general formula (I) R is a halogen atom R is C alkyl C alkenyl C alkynyl C cycloalkyl aryl aralkyl (wherein the alkyl moiety has 1 to 6 carbon atoms) or a heterocyclic group each being optionally substituted R is aryl or a heterocyclic group each being optionally substituted R and R are each a hydrogen atom or the like and R and Rtogether with the nitrogen atom to which R and R are bonded may form an optionally substituted cyclic amino group.
