Composition for preventing ameliorating and treating inflammatory diseases comprising extract of undried immature astrigent persimmon of miyrangbansi as effective component
KANG YOUNG MIN,강영민,PARK JEONG HWAN,박정환,CHOI JI EUN,최지은,JOO SU JI,주수지,YIM NAM HUI,임남희,SHIM KI SHUK,심기석
申请号：
KR1020180159527
公开号：
KR1020190070296A
申请日:
2018.12.11
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a composition for preventing, ameliorating or treating inflammatory diseases, comprising an extract of unripe persimmon calyxes of flat Miryang persimmons harvested in Miryang as an active ingredient. The extract of unripe persimmon calyxes of flat Miryang persimmons harvested in Miryang, which is an active ingredient of the present invention, is highly effective in scavenging nitric oxide (NO), thereby exhibiting excellent anti-inflammation activities. According to results of comparing an extract of unripe persimmon calyxes of flat persimmons, an extract of ripe persimmon calyxes of flat persimmons, and an extract of persimmon calyxes of dried persimmons for each variety, harvested in Gojongsi in Hamyang, Dansung-si in Hamyang, Miryang, of dried persimmons, the extract of unripe persimmon calyxes of flat Miryang persimmons harvested in Miryang described as an active component in the present invention is further effective in scavenging NO. The extract of unripe persimmon calyxes of flat Miryang persimmons harvested in Miryang has no cytotoxicity, and thus has an effect of reducing ear edema caused by dermatitis. Accordingly, the extract can be effectively used as a pharmaceutical composition for anti-inflammation, a composition for a health functional food or a composition for a quasi-drug.본 발명은 밀양 반시의 미성숙 생감꼭지 추출물을 유효성분으로 포함하는 염증성 질환의 예방, 개선 또는 치료용 조성물에 관한 것으로, 본 발명의 유효성분인 밀양 반시의 미성숙 생감꼭지 추출물은 NO(Nitric oxide) 소거능이 우수하여 항염증에 효과가 있으며, 품종별(함양 고종시, 함양 단성시, 밀양 반시) 미성숙 생감꼭지, 성숙 생감꼭지 및 곶감 꼭지를 비교한 결과, 본 발명의 유효성분인 밀양 반시의 미성숙 생감꼭지 추출물이 상대적으로 더 우수한 NO 소거능이 있고, 본 발명의 밀양반시 미성숙 생감꼭지 추출물이 세포 독성이 없으며, 피부염 유발로 인한 귀 부종을 감소시키는 효과가 있으므로, 항염증용 약학 조성물, 건강기능 식품 조성물 또는 의약외품 조성물로 유용하게 사용될 수 있다.
