PYRROLIN-2-ON DERIVATIVES AGAINST TUMOR NECROSIS FACTOR RELEASING CELLS, METHOD OF MANUFACTURE AND APPLICATIONS THEREOF

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专利权人:

TIANJIN HEMAY BIO-TECH CO.; LTD.

发明人:

ZHANG, HESHENG

申请号：

AT07816580

公开号：

AT546454T

申请日:

2007.10.16

申请国别(地区):

AT

年份:

2012

代理人:

摘要：

Compounds represented by Formula (I) or Formula (II), their pharmaceutically acceptable salts or hydrates wherein A, B and E independently represent CH 2 or CO； D represents S, NH, or NC 1-6 alkylhydrocarbyl； R represents H or R 3 , R 1 represents H, or 1-2 same or different occurrences of radical(s) selected from the group consisting of F, Cl, Br, C 1-4 alkylhydrocarbyl, OH, OC 1-4 alkylhydrocarbyl, NO 2 , NHC(O)C 1-4 alkylhydrocarbyl, NH 2 , NH(C 1-4 alkylhydrocarbyl), N(C 1-4 alkylhydrocarbyl) 2 ； and R 2 represents F, CF 3 , H or C 1-4 alkylhydrocarbyl； are active inhibitors of TNF±. Provided are also preparation methods and uses thereof.

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