The present invention relates to an oxygen reaction catalyst composition and a method for preparing the same, more specifically, to an oxygen reaction catalyst composition and a method for preparing the same, capable of continuously removing harmful substances, deodorizing, and sterilizing in a dark room without light as well as under the presence of light, thereby having high usability in every living space such as an inner/outer wall, construction materials, inside of a vehicle, and an inner space without a window. The oxygen reaction catalyst composition is characterized by comprising a first metal (A) selected from the group consisting of titanium, tin, and alloy thereof a second metal (B) of yttrium (Y) and one or more kinds of third metal (C) selected from the group consisting of cobalt (Co), copper (Cu), germanium (Ge), and selenium (Se).COPYRIGHT KIPO 2016본 발명은 산소반응 촉매 조성물 및 그 제조방법에 관한 것으로, 보다 상세하게는 광(빛) 존재하에서 뿐만 아니라, 광(빛)이 없는 무광, 암실에서도 지속적인 유해물질 제거, 탈취, 살균 작용 등을 수행하여, 건축의 내·외벽, 건축자재, 차량의 내부, 창이 없는 내부 등 모든 인간 생활공간에 활용도가 높은 산소반응 촉매 조성물 및 그 제조방법에 관한 것이다.