An object of the present invention is to provide an aqueous composition for topical mucosa which exhibits a histamine release-inhibiting action with a novel formulation which has never been obtained. SOLUTION: An aqueous composition for topical mucosa containing (A) at least one selected from the group consisting of rebamipide, a rebamipide derivative, and a salt thereof, and (B) an oily component is prepared. [Selection diagram] Figure 1【課題】本発明の目的は、従来に無い新規な処方で、ヒスタミン遊離抑制作用を示す局所粘膜用水性組成物を提供することである。【解決手段】（Ａ）レバミピド、レバミピド誘導体、及びその塩からなる群より選択される少なくとも１種、並びに（Ｂ）油性成分を含有する、局所粘膜用水性組成物を調製する。【選択図】図１
