Disclosed is the use of (A) a galectin-1-interactive agent selected from an antibody that is immunointeractive with galectin-1, lactulose, a synthetic analogue of lactulose, a semi-synthetic analogue of lactulose and thiogalactoside and (B) an immune-modulating agent selected from the group consisting of an antigen that corresponds to at least a portion of the target antigen, an antigen-binding molecule that is immuno-interactive with the target antigen and an immune-modulating cell that modulates an immune response to the target antigen, in the manufacture of a medicament for treating or preventing a disease or condition associated with the presence or aberrant expression of a target antigen, wherein the disease or condition is selected from a pathogenic infection, and a disease characterised by immunodeficiency.
