Stabilized human immunodeficiency virus (HIV) envelope (ENV) trimeric vaccine and methods of using the same

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专利权人:

ベス イスラエル デアコネス メディカル センター インコーポレイテッド

发明人:

バロウシュ，ダン，エイチ．,コロラ，ジョーセフ,バロウシュ,ダン,エイチ.,コロラ,ジョーセフ

申请号：

JP2015551842

公开号：

JP6357487B2

申请日:

2014.01.07

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The invention features isolated human immunodeficiency virus (HIV) envelope (Env) trimers, in which the amino acid sequence of the Env polypeptides is optimized to stabilize formation of the trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.

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中国工程科技知识中心

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http://www.ckcest.cn/home/