MERCK SHARP & DOHME CORP.;ALECTOS THERAPEUTICS INC.
发明人:
SELNICK, HAROLD G.,LI, WENPING,HOSTETLER, ERIC,LIU, KUN,MCEACHERN, ERNEST J.,ZHOU, YUANXI,WEI, ZHONGYONG,MU, CHANGWEI,WANG, YAODE,CHANG, JIANG
申请号:
CA2871920
公开号:
CA2871920A1
申请日:
2013.05.03
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and/or hyperphosphorylated tau. The invention is also directed to use of the compounds as O-GlcNAcase imaging agents.