Christina Lorenz,Mariola Fotin-Mleczek,Karl-Josef Kallen
申请号：
US13824502
公开号：
US09737595B2
申请日:
2011.12.27
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex (MHC) class I restricted antigen presentation. The present invention furthermore relates to a method of vaccination of a mammal using the inventive vaccine/inhibitor combination. The present invention also provides kit of parts comprising the inventive vaccine/inhibitor combination, preferably in different parts of the kit, e.g. for prior, concurrent or subsequent administration of the different parts. Additionally the invention relates to a pharmaceutical composition comprising the inventive vaccine/inhibitor combination to further improve the immune response against tumor cells and infected cells having lost the capability of MHC class I restricted antigen presentation.
