roneparstat and roneparstat for use, part kit and part kit for use, pharmaceutical composition, method for treating a mammal and method for inhibiting, treating, and / or preventing multiple myeloma, plasma cell myeloma, recurrent, refractory myeloma or relapsing into a subject
LEADIANT BIOSCIENCES S.A;THE UAB RESEARCH FOUNDATION
发明人:
ALESSANDRO NOSEDA,PAOLA BARBIERI,RALPH D. SANDERSON,VISHNU PRAKASH C. RAMANI
申请号：
BR112017018869
公开号：
BR112017018869A2
申请日:
2016.03.03
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention relates to roneparstat for use in a combination therapy for the treatment of multiple myeloma. In particular, it was unexpectedly found that the combined use of roneparstat with a proteasome inhibitor, in particular selected from bortezomib and carfilzomib or with melphalan, has improved efficacy in decreasing overall tumor burden, especially showing synergism with respect to administration of each active ingredient alone.a presente invenção refere-se ao roneparstat para uso em uma terapia combinada para o tratamento de mieloma múltiplo. em particular, constatou-se inesperadamente que o uso combinado de roneparstat com um inibidor de proteassoma, em particular, selecionado entre bortezomibe e carfilzomib ou com melfalano melhorou a eficácia na diminuição da carga tumoral geral, especialmente que exibe sinergismo, com relação à administração de cada ingrediente ativo sozinho.
