Jeffrey Scholten;MyPhuong Thi Le;Russell Keith Randolph;Richard J. Johnson;Miguel Angel Lanaspa Garcia;Jatinder Rana
发明人:
Jatinder Rana,Russell Keith Randolph,Jeffrey Scholten,MyPhuong Thi Le,Richard J. Johnson,Miguel Angel Lanaspa Garcia
申请号：
US14305876
公开号：
US20140377386A1
申请日:
2014.06.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A composition for inhibiting ketohexokinase, for example, ketohexokinase-C (KHK-C) activity, may include a plant extract exhibiting at least IC50 (i.e., 50% KHK-C inhibition at a concentration in the range of from about 0.1 μg/mL to about 1000 μg/mL. The composition may be in a form suitable for oral ingestion. A method for inhibiting KHK-C activity in a subject may include administering a plant extract that exhibits at least 50% KHK-C inhibition at a concentration from about 0.1 μg/mL to about 1000 μg/mL. The administering may be done to treat or prevent at least one of sugar addiction, obesity, or metabolic syndrome. The administering may be done to provide a diminished craving in the subject from at least one member selected from the group consisting of craving of sugar, fructose, fructose-containing sugars, carbohydrates, and combinations thereof. The subject may be pre-diabetic, diabetic and or insulin resistant.
