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PLANT- BASED INHIBITORS OF KETOHEXOKINASE FOR THE SUPPORT OF WEIGHT MANAGEMENT
专利权人:
发明人:
RANA JATINDER,RANDOLPH RUSSELL KEITH,SCHOLTEN JEFFREY,LE MYPHUONG THI,JOHNSON RICHARD J,LANASPA GARCIA MIGUEL ANGEL
申请号:
IN11451/DELNP/2015
公开号:
IN2015DN11451A
申请日:
2015.12.15
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
A composition for inhibiting ketohexokinase, for example, ketohexokinase-C (KHK-C) activity, may include a plant extract exhibiting at least IC50 (i.e., 50% KHK-C inhibition at a concentration in the range of from about 0.1 g/mL to about 1000 g/mL. The composition may be in a form suitable for oral ingestion. A method for inhibiting KHK-C activity in a subject may inelude administering a plant extract that exhibits at least 50% KHK-C inhibition at a concentration from about 0.1 g/mL to about 1000 g/mL. The administering may be done to treat or prevent at least one of sugar addiction, obesity, or metabolic syndrome. The administering may be done to provide a diminished craving in the subject from at least one member selected from the group consisting of craving of sugar, fructose, fructose-containing sugars, carbohydrates, and combinations thereof. The subject may be pre-diabetic, diabetic and or insulin resistant.
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