1. A method for producing a nanoparticle composition filled with metal substances such as radionuclides, wherein said method comprises: a) providing a nanoparticle composition containing a bubble-forming component and a water-soluble and non-lipophilic chelator surrounded by said bubble-forming component； b) entrapment of metal substances in the inner parts of the composition of nanoparticles by ensuring the transfer of cationic metal substances through the membrane formed by the bubble-forming component, using and incubating the composition of nanoparticles in a solution containing metallic substances, without the use of the ionophore as the transfer molekuly.2. The method according to claim 1, characterized in that the filling or capture efficiency of the radionuclide is more than 10%, namely more than 40%, for example, more than 50%, namely more than 60%, for example, more than 70%, and namely, more than 80%, for example, more than 85%, namely, more than 90%, or, for example, more than 95%, or, for example, more than 97%, or, for example, more than 99%. 3. The method according to claim 1, characterized in that the nanoparticle composition is incubated at a temperature lower than 100 ° C. The method according to claim 3, characterized in that the composition of the nanoparticles is incubated at a temperature of from 10 ° C to 80 ° C, such as from 22 ° C to 80 ° C or such as from 30 ° C to 80 ° C. A method according to any one of the preceding paragraphs, characterized in that the composition of the nanoparticles is incubated for a period of time less than 48 hours. The method according to claim 5, characterized in that the composition of the nanoparticles is incubated for a period of time from 1 to 240 minutes. The method according to claim 6, characterized in that the composition of the nanoparticles is incubated for a period of time, which1. Способ получения композиции наночастиц, заполненной металлическими веществами, такими как радионуклиды, при этом указанный
