Hadwiger, Philipp,Vornlocher, Hans-Peter,Brown, Jonathan Miles,Dahlman, James Everett,Neuman, Kristin K.H.
申请号：
AU2016280709
公开号：
AU2016280709A1
申请日:
2016.06.15
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Defined multi-conjugate oligonucleotides can have predetermined sizes and compositions. For example, in various embodiment, defined multi-conjugate oligonucleotides can have advantageous properties, for example in the form of defined multi-conjugate siRNA (i.e., including two, three or more siRNA) having enhanced intracellular delivery and/or multi-gene silencing effects. In various embodiment, the defined multi-conjugate oligonucleotides can be synthesized via new synthetic intermediates and methods. The defined multi-conjugate oligonucleotides can be used, for example, in reducing gene expression, biological research, treating or preventing medical conditions, or to produce new or altered phenotypes in cells or organisms.
