A motion adjustment prediction system is described. A scan of a dentition is performed to generate a digital dental model from which a position and orientation of each tooth in the upper and lower dental arches of the dentition is determined with respect to each other tooth. A dentition motion assessment is performed to capture motion data representing a movement of the dental arches relative to each other. A dental treatment plan with dentition adjustment is determined based on the scan and the dentition motion assessment. The dentition adjustment can include a restoration preparation, such as a crown or a bridge, or can include an orthodontic alignment. A motion adjustment is predicted based on the dentition adjustment, and the dental treatment plan is modified based on the predicted motion adjustment.