Needle assemblies 500 are disclosed having a multi-purpose protective cap 5. The needle assemblies 500 can embody catheter assembly 120 having a catheter hub 75 and a catheter tube 76 or a hypodermic needle 15 mounted on a needle hub 35. The multi-purpose cap 5 includes a first section 10 covering the needle 15 and a second section 20 having a base portion 40 for covering a hub, such as needle hub 35 or a catheter hub 75. The first section 10 and the second section 20 are separable from one another along a detachment line 30 and the second section 20 is re-useable as a securement device.