Refers to a compound of formula I, where R1 is IL - 2 - 1H pyrrole, pyrrole - 1H - 1H pyrazole or IL 3 - 3 - il R2 is Hydrogen, halogeno, CN, among others R3 and R4 are independently Hydrogen or Methyl, also refers to a compound IB where R1 is 1h pyrazole - 3 - il, R2 is Hydrogen, halogen Among others R4 is Hydrogen or Methyl.Preferred compounds are: 4 - [(2 - (morpholin-4-yl) - 8 - 2H - pyrazole - [il] - 3 - [1,7] - naftiridin - 4-yl] Ethoxycarbonyl - phenyl - N - S - metilsulfoximida 4 - [(2 - (morpholin-4-yl) - 8 - [2H] pyrazole - 3 - il - [1,7] - naftiridin il] - 4 - phenyl - S - metilsulfoximida among others. It also relates to a Composition and a Pharmaceutical combination.These compounds are Derivatives of 2 - (morpholin-4-yl) - 1.7 - naftiridina are useful in the treatment of hyperproliferative DiseasesSe refiere a un compuesto de formula I, donde: R1 es 1H-pirrol-2-il, 1H-pirrol-3-il o 1H-pirazol-3-il R2 es hidrogeno, halogeno, CN, entre otros R3 y R4 son independientemente hidrogeno o metilo, adicionalmente se refiere a una compuesto Ib, donde: R1 es 1H-pirazol-3-il, R2 es hidrogeno, halogeno, entre otros R4 es hidrogeno o metilo. Son compuestos preferidos: 4-[(2-(morfolin-4-il)-8-[2H-pirazol-3-il]-[1,7]-naftiridin-4-il]fenil-N-etoxicarbonil-S-metilsulfoximida 4-[(2-(morfolin-4-il)-8-[2H-pirazol-3-il]-[1,7]-naftiridin-4-il]fenil-S-metilsulfoximida entre otros. Tambien se refiere a una composicion y a una combinacion farmaceutica. Dichos compuestos derivados de 2-(morfolin-4-il)-1,7-naftiridina son utiles en el tratamiento de enfermedades hiperproliferativas
