The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor. Type 2 diabetes is a growing health problem affecting more than 20 million people. Type 2 diabetes is often associated with obesity or with weight gain, although patients with normal weight can also suffer from this disease.La présente invention concerne généralement et en partie des méthodes destinées à entraîner une perte de poids et/ou à améliorer la tolérance au glucose chez un patient en ayant besoin, consistant à administrer un inhibiteur de MetAP2.
