Paolo LAZZARI;Gerard Aime PINNA;Stefania RUIU;Gabrielle MURINEDDU
发明人:
Paolo LAZZARI,Stefania RUIU,Gerard Aime PINNA,Gabrielle MURINEDDU
申请号：
US13327974
公开号：
US20120088751A1
申请日:
2011.12.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Tricyclic pyrazole derivatives of the following formula (I) having affinity for the cannabinoidergic CB1 and/or CB2 receptors:wherein:A represents a group selected from one of the following: (CH2)t—, —(CH2)—S(O)z—, or —S(O)z—(CH2)—,B is a heteroaryl, optionally substituted；R is a group selected from the following: alkyl, aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other；R′ is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R″,a ketonic group of formula —C(O)—Z′, wherein Z′ is as defined below；a substituent having an hydroxyl function of formula —CH(OH)—Z′；an amide substituent of formula —C(O)—NH-T′.
