NONAQUEOUS PRESSURE-SENSITIVE ADHESIVE FOR MEDICINAL TAPE PREPARATION FOR PERCUTANEOUS ABSORPTION, MEDICINAL TAPE PREPARATION FOR PERCUTANEOUS ABSORPTION, AND PROCESS FOR PRODUCING THE SAME
A nonaqueous pressure-sensitive adhesive for a medicinal tape preparation for percutaneous absorption comprising (a) a support, (b) a pressure-sensitive adhesive layer containing a drug and a nonaqueous pressure-sensitive adhesive and (c) a release film laminated in that order, and a medicinal tape preparation for percutaneous absorption comprising the adhesive. The nonaqueous pressure-sensitive adhesive may comprise a copolymer obtained by copolymerization of a (meth)acrylic monomer having an acetoacetyl group in the molecule and one or more monomers from among other (meth)acrylic monomers without acetoacetyl groups and copolymerizable vinyl monomers, in a nonaqueous solvent. Suitable (meth)acrylic monomers having an acetoacetyl group in the molecule are acetoacetoxyalkyl methacrylates, and especially 2-acetoacetoxyethyl methacrylate. The copolymer nonaqueous pressure-sensitive adhesive of the invention, comprising a (meth)acrylic monomer having an acetoacetyl group as a constituent monomer, is capable of containing large amounts of lipophilic oily substances in the pressure-sensitive adhesive layer, and during heat drying, the acetoacetyl groups undergo self-crosslinking to form a network structure as the solvent evaporates off, so that large amounts of oily substances such as the plasticizer can be included in the network structure. The pressure-sensitive adhesive of the invention uses no polyamine derivatives, isocyanate compounds, polyvalent metal chelate compounds, etc. as crosslinking agents, and therefore toxicity is not a concern and skin is not irritated. A medicinal tape preparation for percutaneous absorption of the invention has superior adhesive strength and cohesive strength, and is highly safe with low skin irritation. It also has excellent drug release and percutaneous absorption properties.(a) 지지체, (b) 약제 및 비수성 감압 점착제를 함유하는 감압 점착제층 및 (c) 박리 필름을 순서대로 적층하여 이루어지는 의료용 경피 흡수 테이프 제제 및 상기 점착제를 사용하는 의료용 경피 흡수 테이프 제제용 비수성 감압 점착제.상기 점착제는 비수성 용매 및, 이에 포함된 아
