PROBLEM TO BE SOLVED: To provide a CCR-2 and CCR-5 receptor inhibition activator associated with newborn blood vessels for prophylaxis or therapy of diseases of the posterior segment of the eye, i.e., diseases in a vitreous body, retina, choroid, sclera or optic nerve, associated with neovascularization.SOLUTION: The present invention relates to a prophylactic or therapeutic agent for diseases of the posterior segment of the eye, which contains, as an active ingredient, a 3-amino-2-oxopyrrolidine derivative represented by formula (1), an enantiomer thereof, or a pharmaceutically acceptable salt thereof. [R1, R2 and R4 are each independently H, a lower alkyl group, or a halogen atom-substituted lower alkyl group R3 is H, a halogen atom, a lower alkyl group, or a halogen atom-substituted lower alkyl group R5 is an unsubstituted or R6-substituted nitrogen-containing bicyclic aromatic ring group and R6 is a halogen atom, a lower alkyl group, or a halogen atom-substituted lower alkyl group.]SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】新生血管発現に関係する後眼部疾患、即ち硝子体、網膜、脈絡膜、強膜或いは視神経における疾患の予防又は治療の為に新生血管に関係する、CCR-2及びCCR-5受容体の阻外活性剤の提供。【解決手段】式(1)で示される3-アミノ-2-オキソピロリジン誘導体、そのエナンチオマー又はその薬学的に許容される塩を有効成分として含有する後眼部疾患の予防又は治療剤。[R1、R2及びR4は各々独立にH、低級アルキル基又はハロゲン原子で置換された低級アルキル基;R3はH、ハロゲン原子、低級アルキル基又はハロゲン原子で置換された低級アルキル基;R5は非置換又はR6で置換されている含窒素二環式芳香環基;R6はハロゲン原子、低級アルキル基又はハロゲン原子で置換された低級アルキル基]【選択図】なし
