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DIPHENYL-PYRAZOLOPYRIDINE DERIVATIVES,PREPARATION THEREOF, AND USE THEREOF AS NUCLEAR RECEPTOR NOT MODULATORS
专利权人:
SANOFI
发明人:
AUGER,FLORIAN,EVEN,LUC
申请号:
MYPI 2012002449
公开号:
MY157676A
申请日:
2010.12.03
申请国别(地区):
MY
年份:
2016
代理人:
摘要:
THE INVENTION RELATES TO A FORMULA (I), IN WHICH R IS A HYDROGEN OR HALOGEN ATOM OR A (C1-C6) ALKYL GROUP; X IS ONE OR MORE SUBSTITUENTS SELECTED FROM A HYDROGEN OR HALOGEN ATOM, A (C1-C6)ALKYL, HALO(C1-C6)ALKYL, (C1-C6)ALKOXY, HALO(C1-C6)ALKOXY, CYANO, HYDROXY, OR HYDROXY(C1-C6)ALKYL GROUP; Y IS A HYDROGEN OR HALOGEN ATOM OR A (C1-C6)ALKYL GROUP; R1 IS AN NR2R3 OR OR4 GROUP; R2 AND R3 INDEPENDENTLY ARE A HYDROGEN ATOM, A (C1-C6)ALKYL, HYDROXY(C1-C6)ALKYL OR OXO(C1-C6)ALKYL GROUP, OR R2 AND R3, TOGETHER WITH THE NITROGEN ATOM SUPPORTING THE SAME, FORM A HETEROCYCLE OPTIONALLY SUBSTITUTED BY A (C1-C6)ALKYL, HYDROXY, OR OXO GROUP; AND R4 IS A (C1-C6)ALKYL, HYDROXY(C1-C6)ALKYL, OR OXO(C1-C6)ALKYL GROUP, IN THE BASE OR ACID ADDITION SALT STATE. SAID FORMULA CAN BE USED THERAPEUTICALLY FOR TREATING OR PREVENTING DISEASES LINKED TO THE NUCLEAR RECEPTORS NURR-1, ALSO KNOWN AS NR4A2, NOT, TINUR, RNR-1, AND HZF3
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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