WO 2011/067544 -38 - PCl/F122010/052605AbstractDIPHENYL-PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF AS NUCLEAR RECEPTOR NOT MODULATORSThe invention relates to a formula (I), in which R is a hydrogen or halogen atom or a (C1-C6) alkyl group； X is one or more substituents selected from a hydrogen or halogen 5 atom, a (C1-C6)allcyl, halo(CI-C6)allcyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, cyano, hydroxy, or hydroxy(C1-C6)alkyl group； Y is a hydrogen or halogen atom or a (C1-C6)allcyl group； RI is an NR2R3 or OR4 group； R2 and R3 independently are a hydrogen atom, a (C1-C6)allcyl, hydroxy(C1-C6)allcyl or oxo(C I -C6)alkyl group or R2 and R3, together with the nitrogen atom supporting the same, form a heterocycle optionally substituted by a (C1- 10 C6)allcyl, hydroxy or oxo group； and R4 is a (C1-C6)allcyl, hydroxy(C 1 -C6)allcyl, or oxo(C1-C6)alkyl group, in the base or acid addition salt state. Said formula can be used therapeutically for treating or preventing diseases linked to the nuclear receptors Nun- 1, also known as NR4A2, NOT, T1NUR, RNR-1, and HZE3.
