A method for assessing cancer comprising obtaining a biological sample of the subject, detecting a level of a C-terminal segment of moesin in the biological sample, wherein the level of the C-terminal segment of moesin detected in the biological sample of the subject is indicative of the subject developing or with an increased probability of developing cancer. The present application also provides a biomarker and a kit for assessing cancer, and uses of such biomarker. The present application also provides a method of treating cancer.